H2N2V1, 1957, Analysis, bibRecord, 000037

Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir

Identifieur interne : 000037 ( 1957/Analysis ); précédent : 000036; suivant : 000038

Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir

Auteurs : Jeremy C. Jones ; Tatiana Baranovich ; Bindumadhav M. Marathe ; Angela F. Danner ; Jon P. Seiler ; John Franks ; Elena A. Govorkova ; Scott Krauss ; Robert G. Webster

Source :

Journal of Virology [ 0022-538X ] ; 2014.

RBID : PMC:3911670

Descripteurs français

KwdFr :
- Animaux, Animaux sauvages (virologie), Furets, Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Lignée cellulaire, Oiseaux, Réplication virale, Réservoirs d'agents pathogènes (virologie), Souris, Souris de lignée DBA, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (isolement et purification), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (physiologie), Suidae, Évaluation des risques.
MESH :
- génétique : Sous-type H2N2 du virus de la grippe A.
- isolement et purification : Sous-type H2N2 du virus de la grippe A.
- pathogénicité : Sous-type H2N2 du virus de la grippe A.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- virologie : Animaux sauvages, Grippe chez les oiseaux, Grippe humaine, Réservoirs d'agents pathogènes.
- Animaux, Furets, Humains, Lignée cellulaire, Oiseaux, Réplication virale, Souris, Souris de lignée DBA, Suidae, Évaluation des risques.

English descriptors

KwdEn :
- Animals, Animals, Wild (virology), Birds, Cell Line, Disease Reservoirs (virology), Ferrets, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (isolation & purification), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (physiology), Influenza in Birds (virology), Influenza, Human (virology), Mice, Mice, Inbred DBA, Risk Assessment, Swine, Virus Replication.
MESH :
- genetics : Influenza A Virus, H2N2 Subtype.
- isolation & purification : Influenza A Virus, H2N2 Subtype.
- pathogenicity : Influenza A Virus, H2N2 Subtype.
- physiology : Influenza A Virus, H2N2 Subtype.
- virology : Animals, Wild, Disease Reservoirs, Influenza in Birds, Influenza, Human.
- Animals, Birds, Cell Line, Ferrets, Humans, Mice, Mice, Inbred DBA, Risk Assessment, Swine, Virus Replication.

Abstract

H2N2 influenza A viruses were the cause of the 1957-1958 pandemic. Historical evidence demonstrates they arose from avian virus ancestors, and while the H2N2 subtype has disappeared from humans, it persists in wild and domestic birds. Reemergence of H2N2 in humans is a significant threat due to the absence of humoral immunity in individuals under the age of 50. Thus, examination of these viruses, particularly those from the avian reservoir, must be addressed through surveillance, characterization, and antiviral testing. The data presented here are a risk assessment of 22 avian H2N2 viruses isolated from wild and domestic birds over 6 decades. Our data show that they have a low rate of genetic and antigenic evolution and remained similar to isolates circulating near the time of the pandemic. Most isolates replicated in mice and human bronchial epithelial cells, but replication in swine tissues was low or absent. Multiple isolates replicated in ferrets, and 3 viruses were transmitted to direct-contact cage mates. Markers of mammalian adaptation in hemagglutinin (HA) and PB2 proteins were absent from all isolates, and they retained a preference for avian-like α2,3-linked sialic acid receptors. Most isolates remained antigenically similar to pandemic A/Singapore/1/57 (H2N2) virus, suggesting they could be controlled by the pandemic vaccine candidate. All viruses were susceptible to neuraminidase inhibitors and adamantanes. Nonetheless, the sustained pathogenicity of avian H2N2 viruses in multiple mammalian models elevates their risk potential for human infections and stresses the need for continual surveillance as a component of prepandemic planning.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911670

DOI: 10.1128/JVI.02526-13
PubMed: 24227848
PubMed Central: 3911670

Affiliations:

Links to Exploration step

PMC:3911670

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir</title>
<author><name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name>
</author>
<author><name sortKey="Baranovich, Tatiana" sort="Baranovich, Tatiana" uniqKey="Baranovich T" first="Tatiana" last="Baranovich">Tatiana Baranovich</name>
</author>
<author><name sortKey="Marathe, Bindumadhav M" sort="Marathe, Bindumadhav M" uniqKey="Marathe B" first="Bindumadhav M." last="Marathe">Bindumadhav M. Marathe</name>
</author>
<author><name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name>
</author>
<author><name sortKey="Seiler, Jon P" sort="Seiler, Jon P" uniqKey="Seiler J" first="Jon P." last="Seiler">Jon P. Seiler</name>
</author>
<author><name sortKey="Franks, John" sort="Franks, John" uniqKey="Franks J" first="John" last="Franks">John Franks</name>
</author>
<author><name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A." last="Govorkova">Elena A. Govorkova</name>
</author>
<author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24227848</idno>
<idno type="pmc">3911670</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911670</idno>
<idno type="RBID">PMC:3911670</idno>
<idno type="doi">10.1128/JVI.02526-13</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000676</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000676</idno>
<idno type="wicri:Area/Pmc/Curation">000676</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000676</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000459</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000459</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:24227848</idno>
<idno type="wicri:Area/PubMed/Corpus">000110</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000110</idno>
<idno type="wicri:Area/PubMed/Curation">000110</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000110</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000088</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000088</idno>
<idno type="wicri:Area/Ncbi/Merge">000981</idno>
<idno type="wicri:Area/Ncbi/Curation">000981</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000981</idno>
<idno type="wicri:doubleKey">0022-538X:2014:Jones J:risk:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">000671</idno>
<idno type="wicri:Area/Main/Curation">000670</idno>
<idno type="wicri:Area/Main/Exploration">000670</idno>
<idno type="wicri:Area/1957/Extraction">000037</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir</title>
<author><name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name>
</author>
<author><name sortKey="Baranovich, Tatiana" sort="Baranovich, Tatiana" uniqKey="Baranovich T" first="Tatiana" last="Baranovich">Tatiana Baranovich</name>
</author>
<author><name sortKey="Marathe, Bindumadhav M" sort="Marathe, Bindumadhav M" uniqKey="Marathe B" first="Bindumadhav M." last="Marathe">Bindumadhav M. Marathe</name>
</author>
<author><name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name>
</author>
<author><name sortKey="Seiler, Jon P" sort="Seiler, Jon P" uniqKey="Seiler J" first="Jon P." last="Seiler">Jon P. Seiler</name>
</author>
<author><name sortKey="Franks, John" sort="Franks, John" uniqKey="Franks J" first="John" last="Franks">John Franks</name>
</author>
<author><name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A." last="Govorkova">Elena A. Govorkova</name>
</author>
<author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Animals, Wild (virology)</term>
<term>Birds</term>
<term>Cell Line</term>
<term>Disease Reservoirs (virology)</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (isolation & purification)</term>
<term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H2N2 Subtype (physiology)</term>
<term>Influenza in Birds (virology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred DBA</term>
<term>Risk Assessment</term>
<term>Swine</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Animaux sauvages (virologie)</term>
<term>Furets</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Oiseaux</term>
<term>Réplication virale</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Souris</term>
<term>Souris de lignée DBA</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (isolement et purification)</term>
<term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H2N2 du virus de la grippe A (physiologie)</term>
<term>Suidae</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Animaux sauvages</term>
<term>Grippe chez les oiseaux</term>
<term>Grippe humaine</term>
<term>Réservoirs d'agents pathogènes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animals, Wild</term>
<term>Disease Reservoirs</term>
<term>Influenza in Birds</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Birds</term>
<term>Cell Line</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred DBA</term>
<term>Risk Assessment</term>
<term>Swine</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Furets</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Oiseaux</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée DBA</term>
<term>Suidae</term>
<term>Évaluation des risques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>H2N2 influenza A viruses were the cause of the 1957-1958 pandemic. Historical evidence demonstrates they arose from avian virus ancestors, and while the H2N2 subtype has disappeared from humans, it persists in wild and domestic birds. Reemergence of H2N2 in humans is a significant threat due to the absence of humoral immunity in individuals under the age of 50. Thus, examination of these viruses, particularly those from the avian reservoir, must be addressed through surveillance, characterization, and antiviral testing. The data presented here are a risk assessment of 22 avian H2N2 viruses isolated from wild and domestic birds over 6 decades. Our data show that they have a low rate of genetic and antigenic evolution and remained similar to isolates circulating near the time of the pandemic. Most isolates replicated in mice and human bronchial epithelial cells, but replication in swine tissues was low or absent. Multiple isolates replicated in ferrets, and 3 viruses were transmitted to direct-contact cage mates. Markers of mammalian adaptation in hemagglutinin (HA) and PB2 proteins were absent from all isolates, and they retained a preference for avian-like α2,3-linked sialic acid receptors. Most isolates remained antigenically similar to pandemic A/Singapore/1/57 (H2N2) virus, suggesting they could be controlled by the pandemic vaccine candidate. All viruses were susceptible to neuraminidase inhibitors and adamantanes. Nonetheless, the sustained pathogenicity of avian H2N2 viruses in multiple mammalian models elevates their risk potential for human infections and stresses the need for continual surveillance as a component of prepandemic planning.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Baranovich, Tatiana" sort="Baranovich, Tatiana" uniqKey="Baranovich T" first="Tatiana" last="Baranovich">Tatiana Baranovich</name>
<name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name>
<name sortKey="Franks, John" sort="Franks, John" uniqKey="Franks J" first="John" last="Franks">John Franks</name>
<name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A." last="Govorkova">Elena A. Govorkova</name>
<name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name>
<name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<name sortKey="Marathe, Bindumadhav M" sort="Marathe, Bindumadhav M" uniqKey="Marathe B" first="Bindumadhav M." last="Marathe">Bindumadhav M. Marathe</name>
<name sortKey="Seiler, Jon P" sort="Seiler, Jon P" uniqKey="Seiler J" first="Jon P." last="Seiler">Jon P. Seiler</name>
<name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000037 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000037 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    1957
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:3911670
   |texte=   Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i   -Sk "pubmed:24227848" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir

Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.